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ea0098c21 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

Ratio of total uptake volume on DOTATATE vs FDG PET as a predictive marker of treatment efficacy of Lu-177-DOTATATE in metastatic pheochromocytoma

Lin Frank I. , Del Rivero Jaydira , Carrasquillo Jorge , Shamis Inna , Zou Joy , Turkbey Baris , Jha Abhishek , Klubo Joanna , Adler Steve , Mena Esther , Lindenberg Liza , Chen Clara , Herscovitch Peter , Millo Corina , Pacak Karel

Background: Pheochromocytoma/Paraganglioma (PPGL) are rare neuroendocrine tumors that expresses somatostatin receptors (SSTR) and can be treated with radiolabeled somatostatin analogues such as Lu-177-DOTATATE. Ga-68-DOTATATE PET scans show the distribution and density of SSTR+ tumors, and F-18-FDG PET scans show hypermetabolism in lesions. Total uptake volumes (TUV) for each respective scan can be obtained consistently and semi-automatically using standardized workflow in ima...

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Endocrine Abstracts

Ratio of total uptake volume on DOTATATE vs FDG PET as a predictive marker of treatment efficacy of Lu-177-DOTATATE in metastatic pheochromocytoma

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